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Tea can reduce hypertension

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Good news for tea-drinkers! As one of the largest tea drinkers in the world, Indians can heave a sigh of relief as scientists at the University of California, Irvine and the University of Copenhagen, in Denmark, have found that antioxidants in tea open ion channels and can relax the muscles that line blood vessels. The new study first shows that two antioxidants in tea, known as catechins, open a protein channel in the membranes of the smooth muscle cells that line blood vessels. This allows positively charged potassium ions to leave the cells. They report their findings in the journal Cellular Physiology & Biochemistry.

The study further elaborates how drinking tea is associated with a range of health benefits, including reductions in blood pressure. Both green and black teas are brewed from the leaves of the same shrub, Camellia sinensis, but green tea, which is made from unfermented leaves, contains more antioxidants.

Several studies have found that green tea inhibits the formation of cancers, lowers high blood pressure, and reduces the risk of heart disease. However, the molecular mechanism responsible for the effect on blood pressure has been unclear until now.

Channels in nerve and muscle cells maintain voltages across their membranes by allowing negative and positive ions to pass in and out in a controlled way. They are “voltage-gated,” which means that they respond to changes in this voltage by opening or closing. The researchers found that the catechins in green tea activate a particular type of potassium ion channel, called KCNQ5. When activated, KCNQ5 relaxes blood vessels, making it a logical mechanism for at least part of the hypotensive actions of certain botanical folk medicines, according to the scientists.

The scientists of the Cellular Physiology & Biochemistry study were also involved in similar work that suggested that this protein channel may underlie the antihypertensive effects of several plants that are used as folk or traditional medicines for hypertension.

In summary, activation of the vascular and neuronal KCNQ5 potassium channel contributes significantly to vasodilation by both green and black tea. The tea polyphenols ECG and EGCG are major contributors to this effect, via hyperpolarization of the voltage dependence of KCNQ5 activation. 

UIN: 183HP93R

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Coronavirus

It hasn’t affected kids till now – it won’t affect them ever

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Schools reopening across the globe has brought about a sense of panic in some parents and a sense of confidence in others because vaccination for children is yet to come and unvaccinated children are both at direct risk for COVID as well as at risk of transmitting the virus to others.

According to the World Health Organisation (WHO), data suggests that children under the age of 18 years represent about 8.5% of reported cases, with relatively few deaths compared to other age groups and usually mild disease. However, cases of critical illness have been reported. As with adults, pre-existing medical conditions have been suggested as a risk factor for severe disease and intensive care admission in children. Further studies are underway to assess the risk of infection in children and to better understand transmission in this age group.

Although research has shown that children develop severe disease from COVID-19 far less commonly than adults, and therefore, the risk of death due to severity of COVID-19 is also much lower in children. However, they are not immune. There are reports of children dying due to COVID-19.  But even when children do not get seriously ill with COVID-19 or show symptoms, they can still transmit the virus to other children and adults. The rate of child-to-adult transmission of SARS-CoV-2 is roughly half the rate of adult-to-child transmission. So even when the risk is low for children, transmission to other unvaccinated kids and adults is still a serious concern.

UIN:406HP105F

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Coronavirus

Vaccination can help us tide over the third wave

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The  second wave is declining, although up to 30-40,000 daily new cases continue to be recorded. India is far from being a COVID-19 free nation. Moreover, the looming third wave and alerts released by different State heads to be prepared for a third wave or to make adequate arrangements for the third wave in terms of oxygen cylinders, beds, critical care wards, etc. has kept us all on our toes and inside homes for fear of expediting the arrival of the third wave.

Eminent virologist and retired professor (CMC Vellore), Dr. T Jacob John, in a recent media interview said if the Government can do justice to the vaccination, in terms of making it available in abundance and everywhere, even the unlikely probability of a third wave can be mitigated, adding that in other words, the third wave can be and must be prevented with vaccination. Dr. John also believes that the two strong waves of COVID-19 pandemic in India would have created high herd-immunity, which is why even a moderate level of vaccination will surely avert the third wave.

We should continue to follow physical distancing protocols and avoid crowding indoors or outdoors as much as possible.

UIN: 344HP186R

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Coronavirus

Complete vaccinated individuals three times less likely to get COVID-19

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In what comes as more evidence to back completing the (two-dose or one-dose) mandated course for vaccinations for COVID-19, a recent update published by the Imperial College London has shown that people who have received both doses of their coronavirus vaccine are three times less likely to get infected with COVID-19. These results from the 13th round of the Imperial-led REACT-1 study, a major coronavirus monitoring programme, are based on swab tests taken by almost 100,000 people in England between 24 June and 12 July. 

According to their website, REACT (REal-time Assessment of Community Transmission) is a series of studies that are using home testing to improve the understanding of how the COVID-19 pandemic is progressing across England. This major research programme was commissioned by the Department of Health and Social Care (DHSC) and is being carried out by Imperial College London in partnership with Ipsos MORI and Imperial College Healthcare NHS Trust.

The analysis by Imperial College London and Ipsos MORI, which had almost 100,000 volunteers taking part in the study in England between June 24 and July 12, suggests that double vaccinated people are also less likely to pass on the virus to others. Results have also indicated that people who were fully vaccinated were less likely to be carriers of infection to pass the virus on to others, because they have a lower viral load on average and therefore shed less virus. 

In his statement to the Press post release of study results, the UK Vaccines Minister Mr. Nadhim Zahawi also stated, “these results show the positive impact of the vaccination program with those who are double jabbed three times less likely than unvaccinated people to get the virus and less likely to pass on this awful disease to those around them”.

It is important to note that no vaccine has 100% efficacy but benefits outweigh the risks and therefore vaccination is an important step towards curbing the pandemic. Vaccination however, must also be complemented by COVID appropriate behavior.

UIN 387HP217R

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Fact Check

Hepatitis symptoms differ as per hepatitis type

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Viral hepatitis is mostly caused by the hepatotropic viruses ranging from A to E. Of these, hepatitis A and hepatitis E cause acute hepatitis, but not chronic hepatitis. Hepatitis B and C, on the other hand, can cause either an acute infection or a chronic infection. They are an important cause of liver cirrhosis and hepatocellular carcinoma.

Viral hepatitis is a silent disease as it is mostly asymptomatic in its early stages. This means that the infected persons are not taking the treatment that they need to and are also “silently” transmitting the infection to others. It therefore helps to understand the different clinical symptoms that each type of Hepatitis shows so that if a family member, friend, or you are seeing these symptoms, you should get checked immediately.

While Hep-A infection is an acute and self-limited illness, symptoms can include low grade fever, anorexia, nausea and vomiting, fatigue, malaise, arthralgias, myalgias, headache, photophobia, pharyngitis, cough and coryza. These symptoms may precede onset of jaundice by 1-2 weeks.  Dark urine and clay-colored stools appear 1-5 days before the onset of clinical jaundice and these symptoms may decrease when jaundice becomes evident. The liver becomes enlarged and tender and there may be right upper quadrant pain and discomfort. Hepatitis A in children younger than six years is usually asymptomatic, whereas older children and adults are generally symptomatic.

In Hep-B, rashes, fever, or muscular and bony pains may develop in some cases followed by anorexia, nausea, jaundice, and right upper quadrant discomfort. Most patients with chronic hepatitis B are asymptomatic, while some patients have nonspecific symptoms such as fatigue.

Hepatitis C virus causes both acute and chronic hepatitis. Acute hepatitis C virus infection is the presence of clinical signs or symptoms of hepatitis within 6 months of exposure to the hepatitis C virus. Symptoms of acute hepatitis C are jaundice, nausea, dark urine, and right upper quadrant pain. However, most patients with acute hepatitis C are asymptomatic. Most patients with chronic hepatitis C infection have non-specific symptoms such as fatigue, nausea, anorexia, myalgias, arthralgias, weakness and weight loss.

In Hep-E, some patients may be asymptomatic while others may present with symptoms such as jaundice accompanied by malaise, anorexia, nausea, vomiting, abdominal pain, fever and hepatomegaly. Diarrhea, arthralgia, pruritus and urticarial rash may also be present in some patients.

Acute liver failure can occur; it occurs more frequently during pregnancy, mostly in the third trimester. The mortality rate is high and ranges from 15-25%.

 388HP234R 

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Coronavirus

Breastfeeding post vaccination can kill your baby

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There isn’t any research to support this claim, and based on how vaccines work, there is no reason to believe that the vaccine could harm mom or baby. In fact studies support the fact that the vaccines are not excreted into the breast milk, but antibodies produced by mothers in response to the COVID-19 vaccine do — providing hope that breastfed babies might have some level of protection.

A report published in the journal Nature states that COVID-19 vaccines do not carry a risk of igniting an active infection and that they are extremely unlikely to cross into breast milk. The report further elaborates how the fragile messenger RNA used in the Pfizer–BioNTech and Moderna vaccines, is designed to break down so quickly that it should never leave the cells where it was injected. Therefore, it cannot get into the bloodstream and then the breast. In fact, experts believe none of the current vaccines will be excreted into breast milk.

The World Health Organisation (WHO) Strategic Advisory Group of Experts on Immunization (SAGE) Guidance also recommends that mothers continue to breastfeed after vaccination. The Centre for Disease Control (CDC) and the UK Joint Committee on Vaccination and Immunisation issued statements shortly after the first vaccines were authorized in both countries recommending COVID-19 vaccination for breastfeeding women.

Australia’s Department of Health has indicated that breastfeeding women can get an approved COVID-19 vaccine and don’t need to stop breastfeeding before or after. 

Therefore, in conclusion, no safety concerns have been identified in lactating women who have been vaccinated. Women can continue to breastfeed pre and post COVID-19 vaccination.

 UIN: 400HP104F

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